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Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs.
Cigan AD, Durney KM, Nims RJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. Cigan AD, et al. Tissue Eng Part A. 2016 Sep;22(17-18):1063-74. doi: 10.1089/ten.TEA.2016.0179. Epub 2016 Aug 23. Tissue Eng Part A. 2016. PMID: 27481330 Free PMC article.
Constructs were assessed mechanically for equilibrium compressive Young's modulus (EY), dynamic modulus at 0.01 Hz (G*), and friction coefficient (mu); they were also assessed biochemically, histologically, and immunohistochemically for glycosaminoglycan (GAG) and collagen …
Constructs were assessed mechanically for equilibrium compressive Young's modulus (EY), dynamic modulus at 0.01 Hz (G*), and friction …
Genipin enhances the mechanical properties of tissue-engineered cartilage and protects against inflammatory degradation when used as a medium supplement.
Lima EG, Tan AR, Tai T, Marra KG, DeFail A, Ateshian GA, Hung CT. Lima EG, et al. J Biomed Mater Res A. 2009 Dec;91(3):692-700. doi: 10.1002/jbm.a.32305. J Biomed Mater Res A. 2009. PMID: 19025982 Free PMC article.
The genipin treated groups were also more resistant to cytokine-induced degradation with interleukin-1alpha; maintaining an E(Y) (+218%), G* (+390%) and glycosaminoglycan (GAG) content (+477%) over genipin-untreated constructs subjected to interleukin. ...
The genipin treated groups were also more resistant to cytokine-induced degradation with interleukin-1alpha; maintaining an E(Y) (+218%), …